Tag: Protein

Category: Gonadotropin

The Tie That Binds: CONCLUSIONS

Studies are underway on yoked forms of the other glycoprotein hormones, as well as intersubunit disulfide-linked LH and FSH, and it will be interesting to ascertain similarities and differences. Likewise, studies on yoked LH-LHR, FSH-FSHR,…

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Category: Gonadotropin

The Tie That Binds: YOKED hCG AND DISULFIDE-LINKED SUBUNITS(1)

A number of single-chain hCG agonists have been expressed and characterized, including 0(l-145)-a(l-92), 0(l-123)-a(l-92), and 0-ct(l-92), as well as several with a Ser-Gly spacer—0-(Ser-Gly)5-a(l-92), 0(1-1 ll)-(Ser-Gly)6-a, and 0(l-lO2)-(Ser-Gly)4-a. Also, various unnatural disulfide-linked subunits obtained by…

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