Systemic administration works, but because the medication must hurdle the blood-aqueous barrier, the dose needed is high and systemic toxicity is a real concern. Direct injection is possible, but because it makes a wound, it carries the risks of injury and/or infection. Corneal iontophoresis has not been used because studies done in the 1940s, when the practice was common, showed that the lens-iris barrier effectively blocked the movement of the drug into the posterior chamber.Then came Maurice’s idea, and his work with Baum (Arch Ophthalmol 1984;102:1825-1829 and Ophthalmol 1986;93:128-132,133-139). Basically, they just dusted off this antiquated relic, and moved the point of entry off the cornea, around the globe to the sclera. They had a safer, more effective way to treat bacterial endophthalmitis, a common complication following cataract operations. As they worked, using rabbits, the results suggested slight modifications and refinement in both procedure and apparatus. Find out more about your chance to visit the most trusted pharmacy you could ever find to get viagra discount click here in the amounts required, without any need to see your health care provider first or get a prescription.
The device consists of a small plastic cup that is placed on the sclera, with two tuberculin syringes stuck into the cup. The first syringe is used to create a suction on the scleral surface, holding the device in place on the eye.