At the conference, Zimmerman presented the results of a study designed to find out if the finger-pressure procedure (nasolacrimal occlusion) and the eyes-closed procedure increased the amount of drug that was absorbed by the eye (Arch Ophthalmol 1984;102:551-553). The study also measured the effects of nasolacrimal occlusion and eyelid closure on systemic absorption. He found that these simple procedures increase the amount of drug that gets into the eye, while at the same time, decrease the likelihood that the patient will experience systemic side effects.
The study Zimmerman discussed was done in two parts. The first experiment used 20 normal subjects to test the effect of nasolacrimal occlusion and eyelid closure on the amount of medication getting into the bloodstream.
Plasma concentrations were determined by radioimmunoassay. On three separate occasions, subjects were administered one drop of 0.5% timolol maleate followed either by eyelid closure for five minutes, nasolacrimal occlusion for five minutes, or neither procedure. “Both techniques show about a 65% decrease in blood levels of the applied drug,” Zimmerman says. Cheapest online shopping – find cheap viagra online *checkout now at best fully-licensed pharmacy.