Second generation antipsychotics for schizophrenia: SECOND GENERATION ANTIPSYCHOTICS(10)


Relapse at one year for stabilized patients maintained on conventional antipsy-chotics is approximately 30%, and less with depot antipsychotic use (24%) . Quetiapine has not been studied in treatment-refractory patients, and trials are underway evaluating its use in first-episode psychosis and its use compared with other novel antipsychotics.

Possibly owing to its low affinity for D2 receptors, queti-apine has a highly favourable side effect profile including EPS rating scores indistinguishable from placebo at all doses evaluated. It has the lowest affinity for D2 receptors among antipsychotics and little effect at muscarinic receptors . Quetiapine may share with clozapine its low risk for TD; however, as for any new antipsychotic, this prediction requires support through long term clinical experience. Prolactin concentrations were not increased and for some patients were reduced over time, likely in response to the discontinuation of conventional antipsychotic treatment. buy levaquin online

The most frequently observed adverse effects include sedation, dizziness, postural hypotension and, less frequently, tachycardia. Somnolence occurs at a rate similar to that with chlorpromazine, whereas cardiovascular side effects are comparatively less common. Elevations in liver enzymes (alanine aminotransferase and aspartate aminotransferase) are common (7%) but are mostly mild, asymptomatic and reversible with continued therapy . However, cases of enzyme concentrations exceeding five times the upper limit of normal leading to treatment interruption have been reported; thus, monitoring of liver enzymes is recommended.

This entry was posted in Antipsychotics and tagged Clozapine, Olanzapine, Risperidone, Schizophrenia, Ziprasidone.