Thus, we believe that evidence presented by Rossoni et al on the phenomenon of transcellular synthesis of sLT from PMNL-derived LTA4 by the vascular coronary bed in perfused rabbit heart is of a more generalized nature and is strictly applicable to our lung system. The inhibitory action of BAY X1005 in our experiments proves that the pneumotoxic action of LPS is mediated by sLT, but, most important, it provides new experimental support for the hypothesis that pulmonary tissue can produce significant amounts of sLTs from blood-derived LTA4 via transcellular conversion, which further propagate the effects of LT released from blood cells or other sources . In our opinion transcellular synthesis of sLT can very easily occur in pulmonary circulation because, during LPS-induced sepsis, tight cell to cell interaction is multiplied as a result of progression of disseminated intravascular coagulation .
In summary, our data confirm that pneumotoxic action of LPS is mediated by LTs and that they provide experimental support for the hypothesis concerning transcellular biosynthesis of sLTs from blood cell-derived LTA4 in pulmonary circulation. Significant pulmonary protection by BAY X1005 against LPS-induced lung injury suggests that specific LT synthase inhibitors may provide an innovative approach to therapy of endotoxemia. The best online pharmacy that deserves your trust and gives you best quality Purchase Cheap Claritin that you will always appreciate, not to mention all the other services available.