Pulmonary protection by leukotriene synthesis inhibitor BAY X1005 against lipopolysaccharide-induced injury (part 6)

induced injury (part 6)

DISCUSSION
Intravenous injection of E coli LPS into experimental animals induces septic shock that, mostly fatal, is manifested by systemic hypotension and pulmonary hypertension associated with respiratory failure, vascular injury and disseminated intravascular coagulation . The main clinical complication of shock is acute lung injury (acute respiratory distress syndrome), which is characterized by pulmonary arterial hypertension, obturation of pulmonary blood vessels, increased shunt fraction, formation of atelectasis, arterial hypoxemia and a drop in cardiac output . Thus, the lung seems to be a prime target organ for the toxic action of LPS. Recently, we found that pneumotoxicity of LPS is increased in nitric oxide-deficient, blood-perfused, isolated rat lungs and that pulmonary nitric oxide may play a protective role in endotoxemia in vivo . Nevertheless, although various causative mediators such as nitric oxide, peroxy-nitrates, thromboxane A2, platelet activating factor, tumour necrosis factor, interleukin-1, interferon, serotonin, histamine, angiotensin II and vasopressin have been shown to play a role in septic shock , lung injury in sepsis has been linked mostly to LTs. This has been confirmed in the present study. In a model of blood-perfused rabbit lung in situ, a novel sLT synthesis inhibitor (BAY X1005) was shown to protect lungs against LPS-induced increase in PAP and subsequently against lung injury. Your drugs could be a lot cheaper and your treatment could be still as safe and efficient as always: all you need to do to get your Generic Allegra is shop at the best pharmacy offering its services to you right here right now.

This entry was posted in Lung injury and tagged BAYX1005, Leuko-trienes, Leukotriene synthase inhibitors, Lipopolysaccharide, Lung injury, Septic shock.