Pulmonary protection by leukotriene synthesis inhibitor BAY X1005 against lipopolysaccharide-induced injury (part 1)

lipopolysaccharide-induced injury (part 1)

In the past decade leukotrienes (LTs), formed by 5-lipoxygenase and 5-lipoxygenase-activating protein (FLAP), have been implicated as mediators of ischemic damage and lipopolysaccharide- (LPS) induced shock . Recently it was shown that perfusion of isolated rabbit heart with polymorphonuclear leukocytes (PMNL) induces synthesis of sul-phidopeptide LTs (sLTs), and subsequent damage of coronary circulation and myocardium . BAY X1005, a quino-line inhibitor of sLT synthesis, was shown to have a significant cardioprotective effect in this system. These in vitro findings, reinforced by studies of cardiac ischemia in vivo, strongly support the widely held opinion that suppression of sLT synthesis may be a sufficient pharmacological measure to protect vital organs against ischemia. In addition, these findings add strength to the hypothesis of transcellular metabolism of sLT , which states that the formation of LT is not strictly limited to organs or cells that have primary 5-lipoxygenase and FLAP (eg, PMNL or macrophages). LTB4 and sLTs (LTC4, LTD4 and LTE4) can also be formed in such cells as endothelium , smooth muscle cells , red blood cells (6) and even platelets , which, although deficient in 5-lipoxygenase and FLAP, still possess LTC4-syn-thase or LTA4 hydrolase, orphan enzymes that can make sLT or LTB4, provided that these cells are supplied with LTA4 from PMNL or macrophages. You will always find the required amount of viagra professional canadian pharmacy at the pharmacy that will be happy to take best care of you by offering safe possibility to purchase the drugs you need without any need to get a prescription first or take any other extra steps.

This entry was posted in Lung injury and tagged BAYX1005, Leuko-trienes, Leukotriene synthase inhibitors, Lipopolysaccharide, Lung injury, Septic shock.