Meta-analysis of venlafaxine: DISCUSSION(2)

Meta-analysis of venlafaxine: DISCUSSION(2)

It should be noted that the rates reported are for efficacy rather than effectiveness because they were all produced from RCTs. Interpretation ofthese data and translation into clinical situations require accounting for noncompliance other than that due to ADRs or perceived lack of effect. Other types of noncompliance include (but are not limited to) forgetting to take medication, loss or misplacement of drugs, intentional omission due to fear, perceived lack of need or other personal reasons.

Determining dropout rates are very important in the treatment of MDD because the patient’s condition often deteriorates if untreated. Deterioration may lead to costly hospitalization and other costs to society and families. The impact can be substantial in terms of economics, resource consumption and lives. Buy Asthma Inhalers Online

We made every attempt to locate all available papers; however, 14 were not found. Papers not available through the University of Toronto Library system (one of the largest in Canada) were requested from the reference retrieval system of the National Research Council of Canada in Ottawa. That agency provided many articles but could not locate 14. We doubt that our results are seriously skewed by the absence of those reports.

A number of meta-analyses evaluating antidepressant outcomes have been published . Those comparative studies mainly concentrated on nonelderly adult populations and mainly compared SSRIs with TCAs , possibly due to the widespread use of those drugs and the fact that many prescribers consider SSRIs as ‘first line therapy’.

This entry was posted in Depressive disorder and tagged Depression, Dropouts, Efficacy, Meta-analysis, Selective serotonin reuptake inhibitors, Tricyclic antidepressants.