IN RECENT MONTHS THERE HAS BEEN A GREAT DEAL OF MISINFORMATION concerning the adverse effects of mefloquine after a Canadian military physician suggested that the torture and murder of a Somalian by several Canadian paratroopers might have been related to mefloquine used for malaria chemoprophylaxis.
Severe adverse reactions to mefloquine, namely seizures and psychosis, are rare when the drug is used for prophylaxis, occurring in 1 in 10,000 to 1 in 13,000 users . However, when the drug is used for treatment of malaria, such reactions increase to 1 in 215 to 1 in 1700 users. In a large retrospective study of more than 100,000 travellers who used anti-malarial, side effects from metoloquine occurred in 24% of users compared with 35% for chloroquine and proguanil. Overall, only about 1 % of metoloquine users had to discontinue prophylaxis because of adverse events due to the drug. You will always enjoy getting birth control mircette, being 100% sure you are safe.
The minor neuropsychiatric adverse effects were recently studied in an excellent randomized, double-blind, controlled trial in American troops in Hawaii. There were no statistically significant differences between the side eftects due to mefloquine and those due to chloroquine. However, depressive feelings were two to three times more common in the mefloquine group early in the course of the study, and resolved in the majority of subjects as tolerance developed. This reduction in side eftects over time has been contirmed in a long term study of Peace Corps volunteers.