A significant portion of the extracellular and all of the transmembrane domain of the mink prolactin receptor gene was cloned and sequenced. It had sequence homologies of 78%, 79%, 81%, 84%, and 86% with the rat, mouse, human, bovine, and rabbit prolactin receptor gene sequences, respectively. It also displayed 5354% homology with the rat, human, and rabbit growth hormone receptor gene from the same GH/ prolactin/cytokine receptor superfamily. buy birth control online
In the portion of the extracellular domain cloned, the four cysteine residues, as well as one in the transmembrane domain, are conserved in all prolactin receptor sequences known to date. In keeping with the glycosylation of the prolactin receptor, two potential ^-linked glycosylation sites are present in the extracellular domain of the mink prolactin receptor gene fragment cloned. A recent study has demonstrated that short and long forms of the prolactin receptor are present in the rat CL through pregnancy and that the long form predominates at all stages of gestation. Differences between the forms are due to alterations in the cytoplasmic region of the gene, which was not amplified in the present study.