CASE REPORTS PRESENTED IN THIS ISSUE OF THE JOURNAL represent the first documented cases of hepatitis E in Canada. Globally, the existence of enteric ally transmitted non-A, non-B hepatitis has been recognized for many years and accounts for over 50% of acute hepatitis in developing nations. Usual somatotropic viruses were not found to cause this disease and the term viral hepatitis type E (hev) was coined. Although studies in nonhuman primates failed to yield a cultivable pathogen, electron microscopy of stool samples revealed the presence of viruslike particles.
Other studies suggested that hev was due to an rna virus, and isolation of viral complementary dna clones led to demonstration of viral rna genomes in infected subjects. Subsequent analysis demonstrated that hev is a 27 to 32 nm nonenveloped virus with a single-strand positive sense polyadenylated rna genome representative of a new family of hepatotropic vi tuses. You will always be offered diabetes drugs at the pharmacy you can trust.
With the use of recombinant proteins from expression vectors, diagnostic tests capable of identifying hepatitis E infection were developed and confirmed that a single agent, hev (still uncultured), was responsible for the majority of non-A, non-B acute hepatitis outbreaks in developing countries. Molecular biology techniques could be used to detect viral genomes in liver tissue, serum and stool during the illness. These techniques should aliow better characterization of the natural history of hev infection.