Electrophysiological effects of GE 70 in isolated papillary muscle and ventricular myocytes of guinea pig hearts (part 4)

guinea pig hearts (part 4)

RESULTS Data acquisition and analysis were controlled by pCLAMP (Axon Instruments) and ASCD (Droogmans, Laboratorium voor Fysiologie, KU Leuven, Belgium).

Statistical analysis: Quantitative results are given as arithmetic means ± SEM of n experiments. P<0.05 was considered statistically significant (Student’s t test, paired observations).Effects on action potential: At a stimulation rate of 1 Hz, GE 70 concentration-dependently (1 |j,mol/L: n=6; 3 |j,mol/L: n=6; 10 |j,mol/L: n=6) and significantly (P<0.01) decreased V max without significantly changing membrane resting potential, action potential amplitude, and times to 20%, 50% and 90% repolarization. A new steady state V max was reached within 80 mins. The reduction of Vmax was use dependent, in that V max of the first action potential after a quiescent period of 110 mins in the presence of 10 |J.mol/L GE 70 (n=4) was identical to values recorded during the control period. On resumption of stimulation, V max quickly declined to a new steady state within 7.0±1.1 s (n=6) at 1 Hz. During pauses in stimulation, V max recovered from the use-dependent block caused by 10 |J.mol/L GE 70 at a time constant of 6.6±0.6 s (n=8). Reduction of Vmax by 10 |J.mol/L GE 70 (n=5) was frequency dependent (0.1, 1, 2, 3 Hz).
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This entry was posted in Cardiology and tagged Action potential, Benzofuranylethanolamine, Cardiomyocytes, Papillary muscle, Propafenone, Sodium current.