Comparison of Sarcoidosis Phenotypes Among Affected African-American Siblings: Results

The final study sample consisted of 231 families containing > 2 affected siblings with sarcoidosis comprising a total of 509 affected siblings. Women represented the majority of the affected siblings in the sample (75.1%). Approximately 15% of the enrolled families were comprised of three or more affected siblings, in which all possible sibling pair combinations were counted; there were 197 pairs, 23 trios, 9 quartets, and 2 quintets of affected siblings with sarcoidosis representing a total of 340 affected sibling pairs. Of these, 25% were half-sibling pairs. natural breast enhancement pill
Some phenotype data were missing due to incomplete or unavailable medical records. The degree of missing data for the various organs involved with sarcoidosis ranged from 2% (n = 10) to 11.6% (n = 59). Missing data concerning Scadding radiographic stage and most recent spirometry ranged from 3.7% (n = 19) to 12.2% (n = 62). The only clinical parameters that had > 12.2% of missing data were for FEV1 and FVC closest to the time of the diagnosis of sarcoidosis (28.1% [n = 143] and 28.55% [n = 145], respectively). When the patients with missing spirometry were compared with those with spirometry data available, there were no significant differences in any of the other clinical parameters (data not shown).
Time between diagnosis and most recent spirometry measurements averaged 7.3 years (median, 5.0 years). The mean and SD of FEV1 and FVC among affected siblings at time closest to diagnosis were 2.3 ± 1.1 L and 2.8 ± 0.9 L, respectively. More than 50% of the affected siblings had a change in FVC and FEV1 > 10%, but no significant concordance was found among siblings. Sibling concordance for percentage of predicted FVC and percentage of predicted FEV1 was low (ICCs of 0.27 and 0.23, respectively).
The mean age of affected siblings was 47.0 years (range, 25 to 71 years), and the mean age at diagnosis was 35 years (range, 13 to 68 years). Among sibling pairs, the younger sibling was on average 3 years younger than the older sibling at the time of diagnosis. Sibling concordance for age at diagnosis was weak (ICC = 0.30). Full-sibling pairs and halfsibling pairs were not more likely to be of the same sex than expected by chance alone.

This entry was posted in Sarcoidosis and tagged genetics, phenotype, sarcoidosis, sibling.