Application of warm cardioplegia early in reperfusion resuscitates the ischemic rat heart (part 18)

ischemic rat heart (part 18)

Overall, the positive effect of the hot shot interval on recovery of the macroergic phosphates is almost completely lost in the subsequent KH perfusion interval. The apparently contradictory functional recovery of these hearts remained significantly improved. During the cardioplegic hot shot, the temporary high energy phosphate recovery must be closely related to the very low energy demand of the arrested myocardium. In the ensuing KH reperfusion interval, the high energy requirement of the beating heart causes a gradual loss of the apparent improvement in the recovery of macroergic phosphates. As discussed in the case of the beating heart groups, the final myocardium recovery probably reflects the slow recovery in creatine kinase activity .
In conclusion, the introduction of a short cardioplegic hot shot at the start of the postischemic reperfusion is beneficial to the rat heart. The hot shot protective effect can be achieved within 10 mins of hot shot perfusion. Resuscitation of the rat heart by WBCP is comparable with that by standard warm crystalloid cardioplegic solutions. The advantage of WBCP is that it can be applied at a much reduced flow rate and volumes throughout. You will love this opportunity to shop with best pharmacy on the internet and pay less every time you visit: buy ortho tri-cyclen to discover exactly how much less you could be spending while still getting your treatment exactly the way you need it.

This entry was posted in Ischemic heart and tagged 31P-NMR spectroscopy, Blood cardioplegia, Ischemic heart.