Application of warm cardioplegia early in reperfusion resuscitates the ischemic rat heart (part 16)

On the other hand, the diluted blood group, group 2, displayed a near normal phosphocreatine:ATP ratio (approximately 1.5), probably as a result of improved ATP recovery relative to that of group 1. With about equal calcium ion content for group 1 and group 2 perfusates, the apparent difference in recovery of the ATP pool between the two groups may be related to suboptimal postischemic activity of creatine kinase and the presence of increased amounts of toxic oxygen metabolites in postischemic cells . It was suggested that the well established beneficial antioxidant and free radical scavenging properties of blood attenuate the drop in creatine kinase activity and, hence, the observed high recovery of ATP in group 2 hearts during the hot shot stage.The improved metabolic status of group 2 hearts is also reflected by the quick and complete recovery from deep acidosis, while some parts of the myocardial tissue of group 1 hearts remained acidic at the end of the reperfusion period. Find out more about your chance to visit the most trusted pharmacy you could ever find to get Generic Claritin in the amounts required, without any need to see your health care provider first or get a prescription.

Arrested heart groups: The arrested heart subgroup (groups 3 to 5) yielded very similar phosphocreatine and ATP recoveries that were better than the corresponding recoveries of the beating heart subgroup (see above). Clearly, immediate arrest of the postischemic heart, before being switched to the beating mode, does provide the depleted heart with precious time to boost its energy resources. It is also reflected by the large increase in the phosphocreatine:ATP ratio for groups 3 to 5 (2.5, 2.2 and 2.2, respectively) relative to control group. Because the energy stores are at their lowest level at the end of the ischemia, allowing the postischemic heart to restore even some of its lost energy resources would be advantageous to its long term recovery.

This entry was posted in Ischemic heart and tagged 31P-NMR spectroscopy, Blood cardioplegia, Ischemic heart.