Application of warm cardioplegia early in reperfusion resuscitates the ischemic rat heart (part 11)

 ischemic rat heart (part 11)

The five groups of hearts can be divided into two distinct subgroups, based on metabolic results obtained during the hot shot period (Table 2). One subgroup comprises the three oxygenated cardioplegic interventions, which displayed superior recovery of the phosphocreatine cellular pool, reaching 120% (group 5) and 140% (groups 3 and 4) by the end of the first reperfusion stage (hot shot). The second subgroup comprises groups 1 and 2, which displayed inferior recovery of the phosphocreatine pool (43% and 61%, respectively). The same division, in the degree of recovery, is also evident from analysis of ATP results (Table 2). One notable exception is the warm blood group diluted with KH, group 2, that unexpectedly displayed superior recovery of ATP. All groups reached peak recovery levels within the first 10 mins of the hot shot regimen, and further reperfusion with the same solution did not yield improved recoveries.However, postischemic recovery of the phosphocreatine and ATP cellular pools, obtained at the hot shot stage, were not sustained during subsequent KH reperfusion. Although the differences between the two subgroups were still maintained, they were no longer statistically significant (Table 2). During the second reperfusion stage, the ATP recovery level remained relatively stable while the respective phosphocre-atine level decreased essentially for all groups (Table 2). A significantly higher phosphocreatine level was observed only for group 4 at the end of reperfusion. There is a wonderful pharmacy that you can take advantage of to get the amount of buy cheap alegra you need, and it’s ready to offer its services to you right now, any moment you feel like starting to spend less of your money.

This entry was posted in Ischemic heart and tagged 31P-NMR spectroscopy, Blood cardioplegia, Ischemic heart.