Our in vivo results support and extend previous in vitro observations indicating that bacterial products such as li-popolysaccharides and proinflammatory cytokines inhibit prolactin release from human decidual cells. Furthermore, these data indicate that IL-10 can cross the placental membranes as previously demonstrated and thereby inhibit decidual prolactin secretion directly. In addition, an effect on down-regulation of prolactin transport across fetal membranes via a decrease in prolactin receptor number or activity cannot be excluded. Maternal decidua is a complex tissue composed of stromal cells interspersed with a substantial proportion of bone marrow-derived cells. buy levaquin online
Macrophages, T cells, and natural killer-like large granular lymphocytes constitute approximately 20%, 8%, and 3%, respectively, of third-trimester human decidua. Recently, the expression of monocyte chemoattractant protein 1 in the rat corpus luteum and the recruitment of monocytes (macrophages) have been found to be stimulated by prolactin treatment. Their function is unknown, but it has become apparent that decidual macrophages are a major source of cytokines at the matemo-fetal interface. In addition to functioning as immunoregulatory proteins, cytokines also serve as paracrine mediators that in turn stimulate decidual PG production. An increase in PG production by intrauterine tissues is believed to play a key role in the initiation and propagation of normal labor. PGs have also been implicated as mediators of preterm labor associated with infection.